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In survodutide's Phase 2 trial, indirect calorimetry data (available in a subset of participants) suggested approximately 3-5% increases in resting energy expenditure at the higher doses, which, while modest, represents a genuine thermogenic effect not seen with pure GLP-1 receptor agonists like semaglutide

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Sterile water contains no preservative it is free of microorganisms at the point of manufacture, but that sterility is compromised the moment the vial seal is broken